Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity

• Main Authors: Zhiqin Cao (Author), Shaoyang Li (Author), Jianming Lv (Author), Hao Gao (Author), Guodong Chen (Author), Takayoshi Awakawa (Author), Ikuro Abe (Author), Xinsheng Yao (Author), Dan Hu (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fusidic acid is the only fusidane-type antibiotic that has been clinically used. However, biosynthesis of this important molecule in fungi is poorly understood. We have recently elucidated the biosynthesis of fusidane-type antibiotic helvolic acid, which provides us with clues to identify a possible...