Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity
Fusidic acid is the only fusidane-type antibiotic that has been clinically used. However, biosynthesis of this important molecule in fungi is poorly understood. We have recently elucidated the biosynthesis of fusidane-type antibiotic helvolic acid, which provides us with clues to identify a possible...
Saved in:
Main Authors: | Zhiqin Cao (Author), Shaoyang Li (Author), Jianming Lv (Author), Hao Gao (Author), Guodong Chen (Author), Takayoshi Awakawa (Author), Ikuro Abe (Author), Xinsheng Yao (Author), Dan Hu (Author) |
---|---|
Format: | Book |
Published: |
Elsevier,
2019-03-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy
by: Xiaojun Song, et al.
Published: (2021) -
Stereoselectivity of Aldose Reductase in the Reduction of Glutathionyl-Hydroxynonanal Adduct
by: Francesco Balestri, et al.
Published: (2019) -
Significance and challenges of stereoselectivity assessing methods in drug metabolism
by: Zhuowei Shen, et al.
Published: (2016) -
Enzyme-Mediated Stereoselective Synthesis
by: Serra, Stefano
Published: (2019) -
BIOLOGICAL ROLE OF ALDO-KETO REDUCTASES IN RETINOIC ACID BIOSYNTHESIS AND SIGNALING
by: F. Xavier eRuiz, et al.
Published: (2012)