PEGylation of lipophilic SN38 prodrug with DSPE-mPEG2000 versus cremophor EL: comparative study for intravenous chemotherapy

• मुख्य लेखकों: Jun Zeng (लेखक), Chen Li (लेखक), Xing Duan (लेखक), Fuyue Liu (लेखक), Anqin Li (लेखक), Chunhan Luo (लेखक), Li Jia (लेखक), Yifang Gan (लेखक), Lu Yan (लेखक), Yaxin Zheng (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The lipophilic prodrug of hydrophobic drugs with well-designed molecular structures can form stable pure prodrug nanoparticles (NPs), but rapid NPs aggregation in plasma greatly restricted their direct use for intravenous chemotherapy. To address this, DSPE-mPEG2000 and Cremophor EL are two of the m...