PEGylation of lipophilic SN38 prodrug with DSPE-mPEG2000 versus cremophor EL: comparative study for intravenous chemotherapy

• Main Authors: Jun Zeng (Author), Chen Li (Author), Xing Duan (Author), Fuyue Liu (Author), Anqin Li (Author), Chunhan Luo (Author), Li Jia (Author), Yifang Gan (Author), Lu Yan (Author), Yaxin Zheng (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The lipophilic prodrug of hydrophobic drugs with well-designed molecular structures can form stable pure prodrug nanoparticles (NPs), but rapid NPs aggregation in plasma greatly restricted their direct use for intravenous chemotherapy. To address this, DSPE-mPEG2000 and Cremophor EL are two of the m...