Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ

• Main Authors: Tamara Göbel (Author), Olaf Diehl (Author), Jan Heering (Author), Daniel Merk (Author), Carlo Angioni (Author), Sandra K. Wittmann (Author), Estel.la Buscato (Author), Ramona Kottke (Author), Lilia Weizel (Author), Tim Schader (Author), Thorsten J. Maier (Author), Gerd Geisslinger (Author), Manfred Schubert-Zsilavecz (Author), Dieter Steinhilber (Author), Ewgenij Proschak (Author), Astrid S. Kahnt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cysteinyl leukotriene receptor 1 antagonists (CysLT1RA) are frequently used as add-on medication for the treatment of asthma. Recently, these compounds have shown protective effects in cardiovascular diseases. This prompted us to investigate their influence on soluble epoxide hydrolase (sEH) and per...