Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b

• Main Authors: Adrien Boes (Author), Jean Michel Brunel (Author), Adeline Derouaux (Author), Frédéric Kerff (Author), Ahmed Bouhss (Author), Thierry Touze (Author), Eefjan Breukink (Author), Mohammed Terrak (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peptidoglycan (PG) is an essential polymer of the bacterial cell wall and a major antibacterial target. Its synthesis requires glycosyltransferase (GTase) and transpeptidase enzymes that, respectively, catalyze glycan chain elongation and their cross-linking to form the protective sacculus of the ba...