Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b

• Prif Awduron: Adrien Boes (Awdur), Jean Michel Brunel (Awdur), Adeline Derouaux (Awdur), Frédéric Kerff (Awdur), Ahmed Bouhss (Awdur), Thierry Touze (Awdur), Eefjan Breukink (Awdur), Mohammed Terrak (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2020-07-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Peptidoglycan (PG) is an essential polymer of the bacterial cell wall and a major antibacterial target. Its synthesis requires glycosyltransferase (GTase) and transpeptidase enzymes that, respectively, catalyze glycan chain elongation and their cross-linking to form the protective sacculus of the ba...