Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy

• Main Authors: Xiaosa Chang (Author), Dejuan Sun (Author), Danfeng Shi (Author), Guan Wang (Author), Yanmei Chen (Author), Kai Zhang (Author), Huidan Tan (Author), Jie Liu (Author), Bo Liu (Author), Liang Ouyang (Author)
• Format: Book
• Published: Elsevier, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study was aimed to design the first dual-target small-molecule inhibitor co-targeting poly (ADP-ribose) polymerase-1 (PARP1) and bromodomain containing protein 4 (BRD4), which had important cross relation in the global network of breast cancer, reflecting the synthetic lethal effect. A series o...