Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy

• Hauptverfasser: Xiaosa Chang (Verfasst von), Dejuan Sun (Verfasst von), Danfeng Shi (Verfasst von), Guan Wang (Verfasst von), Yanmei Chen (Verfasst von), Kai Zhang (Verfasst von), Huidan Tan (Verfasst von), Jie Liu (Verfasst von), Bo Liu (Verfasst von), Liang Ouyang (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2021-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

This study was aimed to design the first dual-target small-molecule inhibitor co-targeting poly (ADP-ribose) polymerase-1 (PARP1) and bromodomain containing protein 4 (BRD4), which had important cross relation in the global network of breast cancer, reflecting the synthetic lethal effect. A series o...