Profiling the peripheral immune response to ex vivo TNF stimulation in untreated juvenile idiopathic arthritis using single cell RNA sequencing

• Main Authors: Kathleen J. Imbach (Author), Nicole J. Treadway (Author), Vaishali Prahalad (Author), Astrid Kosters (Author), Dalia Arafat (Author), Meixue Duan (Author), Talia Gergely (Author), Lori A. Ponder (Author), Shanmuganathan Chandrakasan (Author), Eliver E. B. Ghosn (Author), Sampath Prahalad (Author), Greg Gibson (Author)
• Format: Book
• Published: BMC, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Juvenile Idiopathic Arthritis (JIA) is an autoimmune disease with a heterogenous clinical presentation and unpredictable response to available therapies. This personalized transcriptomics study sought proof-of-concept for single-cell RNA sequencing to characterize patient-specifi...