Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension

• Main Authors: Maarouf Baghdadi (Author), Tobias Nespital (Author), Carolina Monzó (Author), Joris Deelen (Author), Sebastian Grönke (Author), Linda Partridge (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Rapamycin, a powerful geroprotective drug, can have detrimental effects when administered chronically. We determined whether intermittent treatment of mice can reduce negative effects while maintaining benefits of chronic treatment. Methods: From 6 months of age, male and female C3B6F1 hy...