Knockdown of PTGS2 by CRISPR/CAS9 System Designates a New Potential Gene Target for Melanoma Treatment

• Main Authors: Giuseppe Ercolano (Author), Paola De Cicco (Author), Valentina Rubino (Author), Giuseppe Terrazzano (Author), Giuseppina Ruggiero (Author), Roberta Carriero (Author), Paolo Kunderfranco (Author), Angela Ianaro (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CRISPR/Cas9 has become a powerful method to engineer genomes and to activate or to repress genes expression. As such, in cancer research CRISPR/Cas9 technology represents an efficient tool to dissect mechanisms of tumorigenesis and to discover novel targets for drug development. Here, we employed th...