Knockdown of PTGS2 by CRISPR/CAS9 System Designates a New Potential Gene Target for Melanoma Treatment

• Hauptverfasser: Giuseppe Ercolano (Verfasst von), Paola De Cicco (Verfasst von), Valentina Rubino (Verfasst von), Giuseppe Terrazzano (Verfasst von), Giuseppina Ruggiero (Verfasst von), Roberta Carriero (Verfasst von), Paolo Kunderfranco (Verfasst von), Angela Ianaro (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

CRISPR/Cas9 has become a powerful method to engineer genomes and to activate or to repress genes expression. As such, in cancer research CRISPR/Cas9 technology represents an efficient tool to dissect mechanisms of tumorigenesis and to discover novel targets for drug development. Here, we employed th...