Knockdown of PTGS2 by CRISPR/CAS9 System Designates a New Potential Gene Target for Melanoma Treatment

• Auteurs principaux: Giuseppe Ercolano (Auteur), Paola De Cicco (Auteur), Valentina Rubino (Auteur), Giuseppe Terrazzano (Auteur), Giuseppina Ruggiero (Auteur), Roberta Carriero (Auteur), Paolo Kunderfranco (Auteur), Angela Ianaro (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

CRISPR/Cas9 has become a powerful method to engineer genomes and to activate or to repress genes expression. As such, in cancer research CRISPR/Cas9 technology represents an efficient tool to dissect mechanisms of tumorigenesis and to discover novel targets for drug development. Here, we employed th...