Knockdown of PTGS2 by CRISPR/CAS9 System Designates a New Potential Gene Target for Melanoma Treatment

• Glavni autori: Giuseppe Ercolano (Autor), Paola De Cicco (Autor), Valentina Rubino (Autor), Giuseppe Terrazzano (Autor), Giuseppina Ruggiero (Autor), Roberta Carriero (Autor), Paolo Kunderfranco (Autor), Angela Ianaro (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

CRISPR/Cas9 has become a powerful method to engineer genomes and to activate or to repress genes expression. As such, in cancer research CRISPR/Cas9 technology represents an efficient tool to dissect mechanisms of tumorigenesis and to discover novel targets for drug development. Here, we employed th...