Knockdown of PTGS2 by CRISPR/CAS9 System Designates a New Potential Gene Target for Melanoma Treatment

• Autori principali: Giuseppe Ercolano (Autore), Paola De Cicco (Autore), Valentina Rubino (Autore), Giuseppe Terrazzano (Autore), Giuseppina Ruggiero (Autore), Roberta Carriero (Autore), Paolo Kunderfranco (Autore), Angela Ianaro (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

CRISPR/Cas9 has become a powerful method to engineer genomes and to activate or to repress genes expression. As such, in cancer research CRISPR/Cas9 technology represents an efficient tool to dissect mechanisms of tumorigenesis and to discover novel targets for drug development. Here, we employed th...