Identification of PI3K-AKT signaling as the dominant altered pathway in intestinal type ampullary cancers through whole-exome sequencing

• Päätekijät: Niraj Kumari (Tekijä), Rajneesh K. Singh (Tekijä), Shravan K. Mishra (Tekijä), Narendra Krishnani (Tekijä), Samir Mohindra (Tekijä), Raghvendra L. (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Korean Society of Pathologists & the Korean Society for Cytopathology, 2021-05-01T00:00:00Z.
• Aiheet: article
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Background The genetic landscape of intestinal (INT) and pancreatobiliary (PB) type ampullary cancer (AC) has been evolving with distinct as well as overlapping molecular profiles. Methods We performed whole-exome sequencing in 37 cases of AC to identify the targetable molecular profiles of INT and...