Identification of PI3K-AKT signaling as the dominant altered pathway in intestinal type ampullary cancers through whole-exome sequencing

• Main Authors: Niraj Kumari (Author), Rajneesh K. Singh (Author), Shravan K. Mishra (Author), Narendra Krishnani (Author), Samir Mohindra (Author), Raghvendra L. (Author)
• Format: Book
• Published: Korean Society of Pathologists & the Korean Society for Cytopathology, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background The genetic landscape of intestinal (INT) and pancreatobiliary (PB) type ampullary cancer (AC) has been evolving with distinct as well as overlapping molecular profiles. Methods We performed whole-exome sequencing in 37 cases of AC to identify the targetable molecular profiles of INT and...