Preservation of vascular endothelial glycocalyx and barrier by activation of adenosine A2A receptor (A2AR) improved renal dysfunction in cirrhotic rats

• Main Authors: Chia-Chang Huang (Author), Hsiao-Chin Shen (Author), Roger Lin (Author), Ying-Ying Yang (Author), Yun-Chien Chang (Author), Tsai-Ling Liao (Author), Shiang-Fen Huang (Author), Han-Chieh Lin (Author), Ming-Chih Hou (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cirrhosis-related hepatic and renal endothelial dysfunction is characterized by macrophage-endothelium adhesion-mediated inflammation, glycocalyx/barrier damage, and impaired vasodilation. Activation of adenosine A2A receptor (A2AR) protects cirrhotic rats from impairment of hepatic microcirculation...