Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies

Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies

Structural-based drug design and solvent-free synthesis were combined to obtain three novel series of 5-arylethylidene-aminopyrimidine-2,4-diones (<b>4</b>, <b>5a</b>-<b>c</b>, <b>6a</b>,<b>b</b>), 5-arylethylidene-amino-2-thiopyrimidine-4-...

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Main Authors: Samar El-Kalyoubi (Author), Samiha A. El-Sebaey (Author), Sherin M. Elfeky (Author), Hanan A. AL-Ghulikah (Author), Mona S. El-Zoghbi (Author)
Format: Book
Published: MDPI AG, 2023-09-01T00:00:00Z.
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