Hot-melt co-extrusion technology as a manufacturing platform for anti-hypertensive fixed-dose combinations

• Main Authors: Ammar Almajaan (Author), Anne-Marie Healy (Author), David Jones (Author), Gareth Colm Gilvary (Author), Gavin Paul Andrews (Author), Jeremiah Francis Kelleher (Author), Shu Li (Author), Yiwei Tian (Author), Zoe Senta-Loys (Author)
• Format: Book
• Published: University of Huddersfield Press, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work focused on the development of a concentric multi-layered fixed-dose combination via an advanced manufacturing technique, hot-melt co-extrusion. The dosage form was designed to offer differing release behaviour; immediate and sustained release from the coat and core, respectively. Hydrochlo...