Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library

• Main Authors: Xingang Wang (Author), Anne L. Robertson (Author), Jingyu Li (Author), Ruth Jinfen Chai (Author), Wang Haishan (Author), Pranvera Sadiku (Author), Nikolay V. Ogryzko (Author), Martin Everett (Author), Kanagasundaram Yoganathan (Author), Hongbo Robert Luo (Author), Stephen A. Renshaw (Author), Philip W. Ingham (Author)
• Format: Book
• Published: The Company of Biologists, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cell migration is fundamental to the inflammatory response, but uncontrolled cell migration and excess recruitment of neutrophils and other leukocytes can cause damage to the tissue. Here we describe the use of an in vivo model - the Tg(mpx:GFP)i114 zebrafish line, in which neutrophils are labelled...