Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library

• Главные авторы: Xingang Wang (Автор), Anne L. Robertson (Автор), Jingyu Li (Автор), Ruth Jinfen Chai (Автор), Wang Haishan (Автор), Pranvera Sadiku (Автор), Nikolay V. Ogryzko (Автор), Martin Everett (Автор), Kanagasundaram Yoganathan (Автор), Hongbo Robert Luo (Автор), Stephen A. Renshaw (Автор), Philip W. Ingham (Автор)
• Формат: ‌
• Опубликовано: The Company of Biologists, 2014-01-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Cell migration is fundamental to the inflammatory response, but uncontrolled cell migration and excess recruitment of neutrophils and other leukocytes can cause damage to the tissue. Here we describe the use of an in vivo model - the Tg(mpx:GFP)i114 zebrafish line, in which neutrophils are labelled...