Timing of Antiviral Treatment Initiation is Critical to Reduce SARS‐CoV‐2 Viral Load

• Main Authors: Antonio Gonçalves (Author), Julie Bertrand (Author), Ruian Ke (Author), Emmanuelle Comets (Author), Xavier deLamballerie (Author), Denis Malvy (Author), Andrés Pizzorno (Author), Olivier Terrier (Author), Manuel Rosa Calatrava (Author), France Mentré (Author), Patrick Smith (Author), Alan S. Perelson (Author), Jérémie Guedj (Author)
• Format: Book
• Published: Wiley, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We modeled the viral dynamics of 13 untreated patients infected with severe acute respiratory syndrome‐coronavirus 2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than two logs, drug efficacy needs to be > 90% if treat...