Sulforaphane-Mediated Nrf2 Activation Prevents Radiation-Induced Skin Injury through Inhibiting the Oxidative-Stress-Activated DNA Damage and NLRP3 Inflammasome

• Main Authors: Jinlong Wei (Author), Qin Zhao (Author), Yuyu Zhang (Author), Weiyan Shi (Author), Huanhuan Wang (Author), Zhuangzhuang Zheng (Author), Lingbin Meng (Author), Ying Xin (Author), Xin Jiang (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This article mainly observed the protective effect of sulforaphane (SFN) on radiation-induced skin injury (RISI). In addition, we will discuss the mechanism of SFN's protection on RISI. The RISI model was established by the irradiation of the left thigh under intravenous anesthesia. Thirty-two...