Optimisation of novel 4, 8-disubstituted dihydropyrimido[5,4-b][1,4]oxazine derivatives as potent GPR 119 agonists

• Main Authors: Yuanying Fang (Author), Shaokun Zhang (Author), Min Li (Author), Lijuan Xiong (Author), Liangxing Tu (Author), Saisai Xie (Author), Yi Jin (Author), Yanhua Liu (Author), Zunhua Yang (Author), Ronghua Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

GPR119 is a promising target for discovery of anti-type 2 diabetes mellitus agents. We described the optimisation of a novel series of pyrimido[5,4-b][1,4]oxazine derivatives as GPR119 agonists. Most designed compounds exhibited good agonistic activities. Among them, compound 10 and 15 demonstrated...