Optimisation of novel 4, 8-disubstituted dihydropyrimido[5,4-b][1,4]oxazine derivatives as potent GPR 119 agonists

• Egile Nagusiak: Yuanying Fang (Egilea), Shaokun Zhang (Egilea), Min Li (Egilea), Lijuan Xiong (Egilea), Liangxing Tu (Egilea), Saisai Xie (Egilea), Yi Jin (Egilea), Yanhua Liu (Egilea), Zunhua Yang (Egilea), Ronghua Liu (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

GPR119 is a promising target for discovery of anti-type 2 diabetes mellitus agents. We described the optimisation of a novel series of pyrimido[5,4-b][1,4]oxazine derivatives as GPR119 agonists. Most designed compounds exhibited good agonistic activities. Among them, compound 10 and 15 demonstrated...