Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection.

• Main Authors: Gurdip Singh Mann (Author), Amanda F Francisco (Author), Shiromani Jayawardhana (Author), Martin C Taylor (Author), Michael D Lewis (Author), Francisco Olmo (Author), Elisangela Oliveira de Freitas (Author), Fabiana M S Leoratti (Author), Cesar López-Camacho (Author), Arturo Reyes-Sandoval (Author), John M Kelly (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:The long term and complex nature of Chagas disease in humans has restricted studies on vaccine feasibility. Animal models also have limitations due to technical difficulties in monitoring the extremely low parasite burden that is characteristic of chronic stage infections. Advances in ima...