Is there a possibility that P‐glycoprotein reduces reproductive toxicity in males but breast cancer resistance protein does not?

• Main Authors: Zhiheng Yu (Author), Wei Liu (Author), Ziyu Wang (Author), Yidong Chen (Author), Jie Yan (Author), Leslie Z. Benet (Author), Suodi Zhai (Author)
• Format: Book
• Published: Wiley, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In traditional understanding, P‐glycoprotein (P‐gp) and Breast Cancer Resistance Protein (BCRP) are regarded as efflux transporters that can decrease the concentration of their substrates in the testis, thereby reducing reproductive toxicity in males (RTM) and protecting spermatogenesis. Ho...