Pre-Clinical Pharmacokinetic Characterization, Tissue Distribution, and Excretion Studies of Novel Edaravone Oral Prodrug, TEJ-1704

• Main Authors: Dong Wook Kang (Author), Ju Hee Kim (Author), Kyung Min Kim (Author), Seok-jin Cho (Author), Hee-Woon Jang (Author), Ji Won Chang (Author), Seung Myung Dong (Author), Jee Woong Lim (Author), Jae-Sun Kim (Author), Hea-Young Cho (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a free radical scavenger approved for the treatment of amyotrophic lateral sclerosis, a fatal neuromuscular disease. Edaravone is administered as an intravenous infusion over 60 min for several treatment cycles. To ease the burden of patients and ca...