Anti-Inflammatory Properties of Chemical Probes in Human Whole Blood: Focus on Prostaglandin E2 Production

• Main Authors: Filip Bergqvist (Author), Yvonne Sundström (Author), Ming-Mei Shang (Author), Iva Gunnarsson (Author), Ingrid E. Lundberg (Author), Michael Sundström (Author), Per-Johan Jakobsson (Author), Louise Berg (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We screened 57 chemical probes, high-quality tool compounds, and relevant clinically used drugs to investigate their effect on pro-inflammatory prostaglandin E2 (PGE2) production and interleukin-8 (IL-8) secretion in human whole blood. Freshly drawn blood from healthy volunteers and patients with sy...