Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts

• Main Authors: Kazuhiro Tamura (Author), Gen Ishikawa (Author), Mikihiro Yoshie (Author), Wakana Ohneda (Author), Akihito Nakai (Author), Toshiyuki Takeshita (Author), Eiichi Tachikawa (Author)
• Formato: Libro
• Publicado: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Infection-associated pregnancy complications cause premature delivery. Caspase-1 is involved in the maturation of interleukin (IL)-1β, which is activated by the NLRP3 inflammasome. To characterize the significance of the NLRP3 inflammasome pathway in the placenta, the effects of activators and inhi...