Phosphorylation at Ser 727 Increases STAT3 Interaction with PKCε Regulating Neuron-Glia Crosstalk via IL-6-Mediated Hyperalgesia In Vivo and In Vitro

• Main Authors: Xiongjuan Li (Author), Biqiang Zhou (Author), Han Yang (Author), Xinping Yang (Author), Zhao Zhao (Author), Zhenglong Pan (Author), Xinran Liao (Author), Wenling Jian (Author), Yuqiang Liu (Author), Han Lu (Author), Qingsheng Xue (Author), Yan Luo (Author), Buwei Yu (Author), Huansen Huang (Author), Daqing Ma (Author), Zhiheng Liu (Author)
• Format: Book
• Published: Hindawi Limited, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Aim. Interleukin-6 (IL-6) modulates neurons-glia crosstalk and subsequently triggers hyperalgesia. This study is aimed at investigating whether the interaction between protein kinase C epsilon (PKCε) and signal transducer and activator of transcription 3 (STAT3) mediated IL-6-induced...