Antiproliferative and Tubulin-Destabilising Effects of 3-(Prop-1-en-2-yl)azetidin-2-Ones and Related Compounds in MCF-7 and MDA-MB-231 Breast Cancer Cells

• Hauptverfasser: Shu Wang (Verfasst von), Azizah M. Malebari (Verfasst von), Thomas F. Greene (Verfasst von), Shubhangi Kandwal (Verfasst von), Darren Fayne (Verfasst von), Seema M. Nathwani (Verfasst von), Daniela M. Zisterer (Verfasst von), Brendan Twamley (Verfasst von), Niamh M. O'Boyle (Verfasst von), Mary J. Meegan (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2023-07-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

A series of novel 3-(prop-1-en-2-yl)azetidin-2-one, 3-allylazetidin-2-one and 3-(buta-1,3-dien-1-yl)azetidin-2-one analogues of combretastatin A-4 (CA-4) were designed and synthesised as colchicine-binding site inhibitors (CBSI) in which the ethylene bridge of CA-4 was replaced with a β-lactam (2-az...