Antiproliferative and Tubulin-Destabilising Effects of 3-(Prop-1-en-2-yl)azetidin-2-Ones and Related Compounds in MCF-7 and MDA-MB-231 Breast Cancer Cells

• Main Authors: Shu Wang (Author), Azizah M. Malebari (Author), Thomas F. Greene (Author), Shubhangi Kandwal (Author), Darren Fayne (Author), Seema M. Nathwani (Author), Daniela M. Zisterer (Author), Brendan Twamley (Author), Niamh M. O'Boyle (Author), Mary J. Meegan (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of novel 3-(prop-1-en-2-yl)azetidin-2-one, 3-allylazetidin-2-one and 3-(buta-1,3-dien-1-yl)azetidin-2-one analogues of combretastatin A-4 (CA-4) were designed and synthesised as colchicine-binding site inhibitors (CBSI) in which the ethylene bridge of CA-4 was replaced with a β-lactam (2-az...