Molecular Mechanisms of the Interactions of <i>N</i>-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins

• Main Authors: Larisa Janisova (Author), Andrey Gruzinov (Author), Olga V. Zaborova (Author), Nadiia Velychkivska (Author), Ondřej Vaněk (Author), Petr Chytil (Author), Tomáš Etrych (Author), Olga Janoušková (Author), Xiaohan Zhang (Author), Clement Blanchet (Author), Christine M. Papadakis (Author), Dmitri I. Svergun (Author), Sergey K. Filippov (Author)
• Format: Book
• Published: MDPI AG, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The binding of plasma proteins to a drug carrier alters the circulation of nanoparticles (NPs) in the bloodstream, and, as a consequence, the anticancer efficiency of the entire nanoparticle drug delivery system. We investigate the possible interaction and the interaction mechanism of a polymeric dr...