Methylglyoxal-Modified Human Serum Albumin Binds to Leukocyte Myeloperoxidase and Inhibits its Enzymatic Activity

• Main Authors: Oleg M. Panasenko (Author), Viktor A. Ivanov (Author), Elena V. Mikhalchik (Author), Irina V. Gorudko (Author), Daria V. Grigorieva (Author), Liliya Yu. Basyreva (Author), Ekaterina V. Shmeleva (Author), Sergey A. Gusev (Author), Valeria A. Kostevich (Author), Nikolay P. Gorbunov (Author), Alexey V. Sokolov (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyperglycemia in diabetes mellitus induces modification of proteins by glucose and its derivative methylglyoxal (MG). Neutrophils perform their bactericidal activity mainly via reactive halogen (RHS) and oxygen (ROS) species generation catalyzed by myeloperoxidase (MPO) stored in neutrophil azurophi...