Recent advances of IDH1 mutant inhibitor in cancer therapy

• Main Authors: Wangqi Tian (Author), Weitong Zhang (Author), Yifan Wang (Author), Ruyi Jin (Author), Yuwei Wang (Author), Hui Guo (Author), Yuping Tang (Author), Xiaojun Yao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Isocitrate dehydrogenase (IDH) is the key metabolic enzyme that catalyzes the conversion of isocitrate to α-ketoglutarate (α-KG). Two main types of IDH1 and IDH2 are present in humans. In recent years, mutations in IDH have been observed in several tumors, including glioma, acute myeloid leukemia, a...