Reevaluation of Serum Arylesterase Activity in Neurodevelopmental Disorders

• Main Authors: Ignazio Stefano Piras (Author), Stefano Gabriele (Author), Laura Altieri (Author), Federica Lombardi (Author), Roberto Sacco (Author), Carla Lintas (Author), Barbara Manzi (Author), Paolo Curatolo (Author), Maria Nobile (Author), Catia Rigoletto (Author), Massimo Molteni (Author), Antonio M. Persico (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Organophosphate compounds (OPs) interfere with neurodevelopment and are neurotoxic for humans and animals. They are first biotransformed to the more toxic oxon form, and then hydrolyzed to specific metabolites by the enzyme paraoxonase/arylesterase, encoded by the gene <i>PON1</i> locate...