Liposomal siRNA Formulations for the Treatment of Herpes Simplex Virus-1: In Vitro Characterization of Physicochemical Properties and Activity, and In Vivo Biodistribution and Toxicity Studies

• Main Authors: Doaa Jbara-Agbaria (Author), Saskia Blondzik (Author), Anke Burger-Kentischer (Author), Majd Agbaria (Author), Mirjam M. Nordling-David (Author), Anna Giterman (Author), Gil Aizik (Author), Steffen Rupp (Author), Gershon Golomb (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Herpes simplex virus-1 (HSV-1) is highly contagious, and there is a need for a therapeutic means to eradicate it. We have identified an siRNA (siHSV) that knocks down gene expression of the infected cell protein 0 (ICP0), which is important in the regulation of HSV infection. The selected siHSV was...