A Promising Vector for TCR Gene Therapy: Differential Effect of siRNA, 2A Peptide, and Disulfide Bond on the Introduced TCR Expression

• Main Authors: Sachiko Okamoto (Author), Yasunori Amaishi (Author), Yumi Goto (Author), Hiroaki Ikeda (Author), Hiroshi Fujiwara (Author), Kiyotaka Kuzushima (Author), Masaki Yasukawa (Author), Hiroshi Shiku (Author), Junichi Mineno (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adoptive immunotherapy using TCR gene-modified T-lymphocytes is an attractive strategy for targeting malignancies. However, TCR mispairings between endogenous and introduced TCR chains are a major concern, as they may induce mixed TCRs with unknown specificities and may reduce the expression of ther...