Developing a JAK Inhibitor for Targeted Local Delivery: Ruxolitinib Cream

• Main Authors: Paul Smith (Author), Wenqing Yao (Author), Stacey Shepard (Author), Maryanne Covington (Author), Jim Lee (Author), Jennifer Lofland (Author), Ahmad Naim (Author), Trupti Sheth (Author), Bhavnish Parikh (Author), Swamy Yeleswaram (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Named after the two-faced Roman god of doorways, Janus kinases (JAKs) represent a class of tyrosine kinases. The JAK signaling pathway is pivotal for the downstream signaling of inflammatory cytokines, including interleukins, interferons, and multiple growth factors. This article provides an overvie...