Antioxidant Effects of PS5, a Peptidomimetic of Suppressor of Cytokine Signaling 1, in Experimental Atherosclerosis

• Main Authors: Sara La Manna (Author), Laura Lopez-Sanz (Author), Susana Bernal (Author), Luna Jimenez-Castilla (Author), Ignacio Prieto (Author), Giancarlo Morelli (Author), Carmen Gomez-Guerrero (Author), Daniela Marasco (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The chronic activation of the Janus kinase/signal transducer and activator of the transcription (JAK/STAT) pathway is linked to oxidative stress, inflammation and cell proliferation. Suppressors of cytokine signaling (SOCS) proteins negatively regulate the JAK/STAT, and SOCS1 possesses a small kinas...