High risk of early sub-therapeutic penicillin concentrations after intramuscular benzathine penicillin G injections in Ethiopian children and adults with rheumatic heart disease.

• Main Authors: Ezra B Ketema (Author), Nigus Z Gishen (Author), Abraha Hailu (Author), Abadi Leul (Author), Abera Hadgu (Author), Kiflom Hagos (Author), Samual Berhane (Author), Temesgen Tsega (Author), Madhu Page-Sharp (Author), Timothy Me Davis (Author), Brioni Moore (Author), Kevin T Batty (Author), Jonathan Carapetis (Author), Sam Salman (Author), Laurens Manning (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Introduction</h4>Intramuscular benzathine penicillin G (BPG) injections are a cornerstone of secondary prophylaxis to prevent acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Uncertainties regarding inter-ethnic and preparation variability, and target exposure profiles...