Distinct or Overlapping Areas of Mitochondrial Thioredoxin 2 May Be Used for Its Covalent and Strong Non-Covalent Interactions with Protein Ligands

• Egile Nagusiak: Charalampos Ntallis (Egilea), Haralampos Tzoupis (Egilea), Theodore Tselios (Egilea), Christos T. Chasapis (Egilea), Alexios Vlamis-Gardikas (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

In silico approaches were employed to examine the characteristics of interactions between human mitochondrial thioredoxin 2 (HsTrx2) and its 38 previously identified mitochondrial protein ligands. All interactions appeared driven mainly by electrostatic forces. The statistically significant residues...