Population Pharmacokinetic, Pharmacogenetic, and Pharmacodynamic Analysis of Cyclophosphamide in Ethiopian Breast Cancer Patients

• Main Authors: Jemal Hussien Ahmed (Author), Eyasu Makonnen (Author), Ronald Kuteesa Bisaso (Author), Jackson Kijumba Mukonzo (Author), Alan Fotoohi (Author), Abraham Aseffa (Author), Rawleigh Howe (Author), Moustapha Hassan (Author), Eleni Aklillu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclophosphamide (CPA) containing chemotherapy regimen is the standard of care for breast cancer treatment in sub-Saharan Africa. Wide inter-individual variations in pharmacokinetics (PK) of cyclophosphamide (CPA) influence the efficacy and toxicity of CPA containing chemotherapy. Data on the pharma...