Calculation of therapeutic antibody viscosity with coarse-grained models, hydrodynamic calculations and machine learning-based parameters

• Hauptverfasser: Pin-Kuang Lai (Verfasst von), James W. Swan (Verfasst von), Bernhardt L. Trout (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

High viscosity presents a challenge for manufacturing and drug delivery of therapeutic antibodies. The viscosity is determined by protein-protein interactions among many antibodies. Molecular simulation is a promising method to study protein-protein interactions; however, all-atom models do not allo...