Effect of nitazoxanide on albendazole pharmacokinetics in cerebrospinal fluid and plasma in rats

• Main Authors: María Isabel Ruiz-Olmedo (Author), Iliana González-Hernández (Author), Francisca Palomares-Alonso (Author), Javier Franco-Pérez (Author), María de Lourdes González F. (Author), Helgi Jung-Cook (Author)
• Format: Book
• Published: Elsevier, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Although albendazole is the drug-of-choice for the treatment of neurocysticercosis, its efficacy is limited due to its low bioavailability. An alternative for optimizing pharmacological treatment is through drug combinations. In vitro studies have shown that nitazoxanide and tizoxanide (...