Influence of Ecto-nucleoside triphosphate diphosphohydrolase activity on Trypanosoma cruzi infectivity and virulence.

• Main Authors: Ramon F Santos (Author), Marcela A S Pôssa (Author), Matheus S Bastos (Author), Paulo M M Guedes (Author), Márcia R Almeida (Author), Ricardo Demarco (Author), Sergio Verjovski-Almeida (Author), Maria T Bahia (Author), Juliana L R Fietto (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The protozoan Trypanosoma cruzi is the causative agent of Chagas disease. There are no vaccines or effective treatment, especially in the chronic phase when most patients are diagnosed. There is a clear necessity to develop new drugs and strategies for the control and treatment of Chagas...