Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy

Series of 1,3-disubstituted ureas and diadamantyl disubstituted diureas with fluorinated and chlorinated adamantane residues were shown to inhibit human soluble epoxide hydrolase (sEH) with inhibition potency ranging from 40 pM to 9.2 nM. The measured IC50 values for some molecules were below the ac...

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Hoofdauteurs: Vladimir V. Burmistrov (Auteur), Christophe Morisseau (Auteur), Dmitry V. Danilov (Auteur), Boris P. Gladkikh (Auteur), Vladimir S. D'yachenko (Auteur), Nikolay A. Zefirov (Auteur), Olga N. Zefirova (Auteur), Gennady M. Butov (Auteur), Bruce D. Hammock (Auteur)
Formaat: Boek
Gepubliceerd in: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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3rd Floor Main Library

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Plaatsingsnummer: A1234.567
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