Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy

• Main Authors: Vladimir V. Burmistrov (Author), Christophe Morisseau (Author), Dmitry V. Danilov (Author), Boris P. Gladkikh (Author), Vladimir S. D'yachenko (Author), Nikolay A. Zefirov (Author), Olga N. Zefirova (Author), Gennady M. Butov (Author), Bruce D. Hammock (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Series of 1,3-disubstituted ureas and diadamantyl disubstituted diureas with fluorinated and chlorinated adamantane residues were shown to inhibit human soluble epoxide hydrolase (sEH) with inhibition potency ranging from 40 pM to 9.2 nM. The measured IC50 values for some molecules were below the ac...