Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity

• Main Authors: Kristin E. Claflin (Author), Andrew I. Sullivan (Author), Meghan C. Naber (Author), Kyle H. Flippo (Author), Donald A. Morgan (Author), Tate J. Neff (Author), Sharon O. Jensen-Cody (Author), Zhiyong Zhu (Author), Leonid V. Zingman (Author), Kamal Rahmouni (Author), Matthew J. Potthoff (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Fibroblast growth factor 21 (FGF21) is a peripherally-derived endocrine hormone that acts on the central nervous system (CNS) to regulate whole body energy homeostasis. Pharmacological administration of FGF21 promotes weight loss in obese animal models and human subjects with obesity. How...