GLIS3: A novel transcriptional regulator of mitochondrial functions and metabolic reprogramming in postnatal kidney and polycystic kidney disease

• Main Authors: Justin B. Collier (Author), Hong Soon Kang (Author), Yun-Gil Roh (Author), Chitrangda Srivastava (Author), Sara A. Grimm (Author), Alan K. Jarmusch (Author), Anton M. Jetten (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Deficiency in the transcription factor (TF) GLI-Similar 3 (GLIS3) in humans and mice leads to the development of polycystic kidney disease (PKD). In this study, we investigate the role of GLIS3 in the regulation of energy metabolism and mitochondrial functions in relation to its role in...