Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies

• Main Authors: Satsuki Hashimoto (Author), Kyoko Honda (Author), Kohei Fujita (Author), Yuka Miyachi (Author), Kazuya Isoda (Author), Ko Misaka (Author), Yukio Suga (Author), Satoshi Kato (Author), Hiroyuki Tsuchiya (Author), Yukio Kato (Author), Masaki Okajima (Author), Takumi Taniguchi (Author), Tsutomu Shimada (Author), Yoshimichi Sai (Author)
• Format: Book
• Published: BMC, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Combination therapy of linezolid (LZD) and rifampicin (RFP) may be more effective than monotherapy for treating gram-positive bacterial infections, but several studies have suggested that RFP decreases LZD exposures, thereby increasing the risk of therapeutic failure and emergenc...