Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer's Disease

• Главные авторы: Mikko Gynther (Автор), Mariana Leal Estrada (Автор), Sanna Loppi (Автор), Paula Korhonen (Автор), Katja M. Kanninen (Автор), Tarja Malm (Автор), Jari Koistinaho (Автор), Seppo Auriola (Автор), Gert Fricker (Автор), Elena Puris (Автор)
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• Опубликовано: MDPI AG, 2022-11-01T00:00:00Z.
• Предметы: article
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Cytosolic phospholipase A2 (cPLA2) is an enzyme regulating membrane phospholipid homeostasis and the release of arachidonic acid utilized in inflammatory responses. It represents an attractive target for the treatment of Alzheimer's disease (AD). Previously, we showed that lipopolysaccharide (L...