Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer's Disease

• Main Authors: Mikko Gynther (Author), Mariana Leal Estrada (Author), Sanna Loppi (Author), Paula Korhonen (Author), Katja M. Kanninen (Author), Tarja Malm (Author), Jari Koistinaho (Author), Seppo Auriola (Author), Gert Fricker (Author), Elena Puris (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cytosolic phospholipase A2 (cPLA2) is an enzyme regulating membrane phospholipid homeostasis and the release of arachidonic acid utilized in inflammatory responses. It represents an attractive target for the treatment of Alzheimer's disease (AD). Previously, we showed that lipopolysaccharide (L...