Mannitol-Coated Hydroxypropyl Methylcellulose as a Directly Compressible Controlled Release Excipient for Moisture-Sensitive Drugs: A Stability Perspective

• Main Authors: Christina Yong Xin Kang (Author), Keat Theng Chow (Author), Yuan Siang Lui (Author), Antoine Salome (Author), Baptiste Boit (Author), Philippe Lefevre (Author), Tze Ning Hiew (Author), Rajeev Gokhale (Author), Paul Wan Sia Heng (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Objectives: Hydroxypropyl methylcellulose (HPMC) is one of the most commonly used hydrophilic polymers in formulations of matrix tablets for controlled release applications. However, HPMC attracts moisture and poses issues with drug stability in formulations containing moisture-sensitive...