Impact of sample acquisition and linear amplification on gene expression profiling of lung adenocarcinoma: laser capture micro-dissection cell-sampling versus bulk tissue-sampling

• Main Authors: Wigle Dennis A (Author), Sun Zhifu (Author), Kosari Farhad (Author), Tillmans Lori (Author), Erdogan Sibel (Author), Klee Eric W (Author), Yang Ping (Author), Aubry Marie C (Author), Vasmatzis George (Author)
• Format: Book
• Published: BMC, 2009-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The methods used for sample selection and processing can have a strong influence on the expression values obtained through microarray profiling. Laser capture microdissection (LCM) provides higher specificity in the selection of targ...