TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis

• Main Authors: Yiting Tang (Author), Rui Zhang (Author), Qianqian Xue (Author), Ran Meng (Author), Xiangyu Wang (Author), Yanliang Yang (Author), Lingli Xie (Author), Xianzhong Xiao (Author), Timothy R. Billiar (Author), Ben Lu (Author)
• Format: Knjiga
• Izdano: BMC, 2018-12-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract Background Caspase-11, a cytosolic receptor of bacterial endotoxin (lipopolysaccharide: LPS), mediates immune responses and lethality in endotoxemia and experimental sepsis. However, the upstream pathways that regulate caspase-11 activation in endotoxemia and sepsis are not fully understood...